The Control key is often used, the Caps Lock key is not. Therefore, it makes
sense to swap them. On X11 systems, it is as simple as running setxkbmap
-option ctrl:swapcaps.
This reduces the strain put on the left pinky and makes control + alt +
key keybindings viable as the left hand simply has to slide to the left
for the thumb and pinky to be in the right position.
Moreover, this makes hitting <C-[> more comfortable than
<Esc> to switch to Normal Mode in Vim. Alternatively, using a
program like xcape
enables using the Caps Lock key as both Escape or Control, depending on whether
it is used as a single key or modifier.